Bridging the Gap: A Systematic Review with Expert Opinion on the Use of Dalbavancin for In-Label and Off-Label Indications in Pediatric Patients

Objectives: The aim of this work was to perform a systematic review assessing the pharmacokinetic/pharmacodynamic (PK/PD) properties of dalbavancin and the clinical use for in-label and off-label indications in pediatric patients.Methods: Two authors independently searched the PubMed-MEDLINE and Scopus databases and clinicaltrials.gov up to 20 Nove

read more

Catastrophe Information Characteristics and Prevention Measures of Water Inrush in Tunnel Approaching Fault with Different Water Pressure

In order to ensure the safety of the tunnel approaching the fault and prevent water inrush disasters, and then take reasonable protective measures, a fault-tunnel-surrounding rock is established by using a three-dimensional (3D) discrete element numerical analysis method, which takes into account the fluid-structure coupling effect.Based on the met

read more


Access to Palliative Care for Cancer Patients Living in a Northern and Rural Environment in Ontario, Canada: The Effects of Geographic Region and Rurality on End-of-Life Care in a Population-Based Decedent Cancer Cohort

Background: Access to palliative care has been associated with improving quality of life and reducing the use of potentially aggressive end-of-life care.However, many challenges Diodes and barriers exist in providing palliative care to residents in northern and rural settings in Ontario, Canada.Aim: The purpose of this study was to examine access t

read more